October 30th, 2021
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 102 | Mary Kay Campbell | 935 | 45 | F | Roanoke VA | 34:47.3 | 11:21/M | 1:F 45-49 |
| 119 | Kathryn Mustard | 806 | 46 | F | Roanoke VA | 37:07.2 | 12:03/M | 2:F 45-49 |
| 121 | Allison Moser | 944 | 49 | F | Roanoke | 37:18.2 | 12:06/M | 3:F 45-49 |
| 124 | Angela Crockett | 652 | 48 | F | Roanoke | 38:00.2 | 12:23/M | 4:F 45-49 |
| 141 | Kelly Bennington | 634 | 45 | F | Roanoke | 39:53.4 | 12:59/M | 5:F 45-49 |
| 151 | Andra Blatt | 940 | 46 | F | 43:01.4 | 13:59/M | 6:F 45-49 | |
| 152 | Suzanne Smith | 934 | 45 | F | Rocky Mount VA | 43:02.0 | 13:59/M | 7:F 45-49 |
| 155 | Robyn Goodman | 925 | 48 | F | 43:27.0 | 14:05/M | 8:F 45-49 | |
| 172 | Kimberly Cash | 931 | 46 | F | Roanoke VA | 49:06.0 | 17:56/M | 9:F 45-49 |
| 187 | Lori Geist | 824 | 45 | F | Vinton VA | 54:43.1 | 17:52/M | 10:F 45-49 |