October 30th, 2021
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 22 | Rachel Defibaugh | 999 | 36 | F | Roanoke VA | 25:06.4 | 8:16/M | 1:F 35-39 |
| 24 | Nicki Shearer | 963 | 39 | F | Roanoke VA | 25:17.9 | 8:15/M | 2:F 35-39 |
| 48 | Jamie Brackenrich | 820 | 36 | F | Roanoke VA | 28:20.8 | 9:18/M | 3:F 35-39 |
| 58 | Krista Scruggs | 670 | 38 | F | Salem VA | 29:07.7 | 9:27/M | 4:F 35-39 |
| 59 | Allison Bowersock | 623 | 39 | F | Roanoke VA | 29:09.3 | 9:39/M | 5:F 35-39 |
| 76 | Andrea Clements | 936 | 35 | F | Roanoke VA | 31:25.1 | 10:11/M | 6:F 35-39 |
| 80 | Kori Banyas | 826 | 36 | F | Roanoke VA | 31:30.6 | 10:19/M | 7:F 35-39 |
| 92 | Amy Andrews | 864 | 35 | F | 33:03.1 | 10:49/M | 8:F 35-39 | |
| 96 | Sara Miller | 640 | 39 | F | 33:52.0 | 10:58/M | 9:F 35-39 | |
| 106 | Heather Conway | 654 | 35 | F | 35:27.6 | 11:37/M | 10:F 35-39 | |
| 111 | Kelly Prim | 699 | 39 | F | Roanoke VA | 36:28.0 | 11:52/M | 11:F 35-39 |
| 142 | Kimberly Forrest | 929 | 35 | F | Roanoke VA | 39:55.4 | 13:06/M | 12:F 35-39 |
| 147 | Jennifer Arthur | 622 | 36 | F | Roanoke VA | 41:03.8 | 13:20/M | 13:F 35-39 |
| 150 | Sarah Holdren | 807 | 38 | F | Roanoke VA | 42:42.6 | 13:59/M | 14:F 35-39 |
| 184 | Katie Taylor | 692 | 35 | F | Salem VA | 52:05.1 | 16:59/M | 15:F 35-39 |
| 193 | Nikki Allen | 696 | 35 | F | Roanoke VA | 58:04.3 | 18:52/M | 16:F 35-39 |
| 194 | Jessica Williams | 656 | 39 | F | Roanoke VA | 58:09.1 | 18:55/M | 17:F 35-39 |