October 23rd, 2021
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 39 | Mattie Radford | 868 | 46 | F | Roanoke VA | 37:45.94 | 9:26/M | 1:F 45-49 |
| 52 | Kim Kitts | 776 | 48 | F | Christiansburg VA | 39:53.79 | 9:58/M | 2:F 45-49 |
| 68 | Jennifer Wills | 739 | 46 | F | Lynchburg VA | 42:06.63 | 10:32/M | 3:F 45-49 |
| 87 | Jennifer White | 782 | 48 | F | Roanoke VA | 46:49.43 | 11:42/M | 4:F 45-49 |
| 125 | Donna Shutts | 841 | 46 | F | Fincastle | 53:10.16 | 13:18/M | 5:F 45-49 |
| 130 | Maureen Roberts | 905 | 49 | F | Salem VA | 53:19.99 | 13:20/M | 6:F 45-49 |
| 133 | April Joachim | 766 | 48 | F | Salem VA | 53:44.63 | 13:26/M | 7:F 45-49 |
| 161 | Susan Guelich | 822 | 45 | F | 1:03:50.40 | 15:58/M | 8:F 45-49 | |
| 168 | Heather Walker | 787 | 47 | F | Roanoke VA | 1:06:31.31 | 16:38/M | 9:F 45-49 |
| 172 | Bridgette Tattersall | 819 | 48 | F | Athens WV | 1:11:01.47 | 17:45/M | 10:F 45-49 |