September 4th, 2021
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 10 | Lauren Clifford | 312 | 30 | F | Black Mountain NC | 5:13:34.3 | 10:27/M | 1:Open |
| 15 | Ashley Goodman | 335 | 48 | F | Boone NC | 5:23:05.6 | 10:46/M | 2:Open |
| 21 | Emma Helm | 341 | 27 | F | Blacksburg VA | 5:30:05.7 | 11:00/M | 3:Open |
| 27 | Natalie Daniel | 323 | 44 | F | Mount Holly NC | 5:49:07.1 | 11:38/M | 1:F 40-44 |
| 33 | Rafaela George | 333 | 55 | F | Cary NC | 5:55:22.4 | 11:51/M | 1:F 55-59 |
| 35 | Ariana Donovan | 327 | 28 | F | Myrtle Beach SC | 6:05:06.2 | 12:10/M | 1:F 25-29 |
| 37 | Aimee Trepanier | 389 | 32 | F | Greenville SC | 6:14:44.7 | 12:29/M | 1:F 30-34 |
| 39 | Jennie Wyderko | 399 | 32 | F | Blacksburg VA | 6:18:24.1 | 12:37/M | 2:F 30-34 |
| 41 | Sondra Setterington | 377 | 35 | F | Fayetteville NC | 6:25:18.7 | 12:51/M | 1:F 35-39 |
| 42 | Bailey Thomas | 386 | 13 | F | Evington VA | 6:28:23.5 | 12:57/M | 1:F 1-19 |
| 43 | Annette Stevens | 384 | 30 | F | Kingsport TN | 6:28:58.9 | 12:58/M | 3:F 30-34 |
| 45 | Sally Brooking | 306 | 64 | F | Marietta GA | 6:38:39.2 | 13:17/M | 1:F 60-64 |
| 48 | Jennifer Nelson | 361 | 40 | F | Blacksburg VA | 6:43:03.8 | 13:26/M | 2:F 40-44 |
| 50 | Molly Freeman | 332 | 45 | F | Decatur GA | 6:45:26.2 | 13:31/M | 1:F 45-49 |
| 51 | Rachel Duran | 328 | 33 | F | Myrtle Beach SC | 6:51:33.0 | 13:43/M | 4:F 30-34 |
| 52 | Chelsie Viar | 392 | 41 | F | Lynchburg VA | 6:55:46.9 | 13:52/M | 3:F 40-44 |
| 54 | Jeannette Pantani | 364 | 52 | F | Charlotte NC | 6:58:42.7 | 13:57/M | 1:F 50-54 |
| 55 | Leslie Smith | 381 | 43 | F | Johnson City TN | 7:02:11.9 | 14:04/M | 4:F 40-44 |
| 56 | Cora Player | 367 | 47 | F | Fort Mill SC | 7:13:05.4 | 14:26/M | 2:F 45-49 |
| 57 | Tracy Proffitt | 370 | 39 | F | Lynchburg VA | 7:20:38.3 | 14:41/M | 2:F 35-39 |
| 59 | Kathleen Gorman | 336 | 61 | F | Roanoke VA | 7:25:45.2 | 14:52/M | 2:F 60-64 |
| 60 | Dru Sexton | 378 | 69 | F | Roanoke VA | 7:25:46.7 | 14:52/M | 1:F 65-99 |
| 61 | Elizabeth Johnson | 348 | 40 | F | Roanoke VA | 7:32:12.6 | 15:04/M | 5:F 40-44 |
| 63 | Nicky Buckley | 309 | 47 | F | Damascus VA | 7:36:52.1 | 15:14/M | 3:F 45-49 |
| 65 | Jenny Bonner | 304 | 33 | F | Oviedo FL | 7:41:33.6 | 15:23/M | 5:F 30-34 |
| 70 | Ercilia Ward | 4027 | 41 | F | Roanoke VA | 7:47:17.4 | 15:35/M | 6:F 40-44 |
| 73 | Leslie Taylor | 385 | 57 | F | Greensboro NC | 7:55:45.4 | 15:52/M | 2:F 55-59 |
| 75 | Stacy Saunders | 376 | 42 | F | Ashland KY | 8:11:41.6 | 16:23/M | 7:F 40-44 |
| 78 | Emily Clymer | 313 | 41 | F | Cincinnati OH | 8:15:45.3 | 16:32/M | 8:F 40-44 |
| 79 | Samantha Brown | 307 | 20 | F | Richlands VA | 8:41:53.2 | 17:24/M | 1:F 20-24 |